Journal of Animal Breeding and Genomics (J Anim Breed Genom)
Indexed in KCI
OPEN ACCESS, PEER REVIEWED
pISSN 1226-5543
eISSN 2586-4297
Research Article

Genome-wide Association Study using the Canine SNP20 Beadchip for Canine Hip Dysplasia in Labrador Retriever

1Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Wanju, 55365, South Korea
2Animal Disease & Biosecurity Team, National Institute of Animal Science, RDA, Wanju, 55365, South Korea
3Division of Animal and Dairy Science, Chungnam National University, Daejeon, Korea

Correspondence to Seung Hwan Lee, E-mail: slee46@cnu.ac.kr

Volume 3, Number 1, Pages 7-15, March 2019.
Journal of Animal Breeding and Genomics 2019, 3(1), 7-15. https://doi.org/10.12972/jabng.20190002
Received on 16 March, 2019, Revised on 20 March, 2019, Accepted on 30 May, 2019, Published on March 31, 2019.
Copyright © 2019 Korean Society of Animal Breeding and Genetics.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).

ABSTRACT

Many dog genetic disease, which can mean that the rate of inbreeding is the result. Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints and one of the most important bone and joint diseases. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis. The radiographic diagnosis is sometime possible when the disease has markedly progressed. Looking up now studies with dog genetic disease a dwarfism (Germany shepherd), progressive retinal atrophy (Mastiff), malignant fever (all variety). With molecular biological techniques are being developed. This study, the hip dysplasia and early diagnosis that can be genetic markers to develop a more 22K SNP chip using the hip dysplasia in the X-ray diagnostics have Labrador retriever 48 of blood from the Wizard Genomic DNA Purification Kit using the DNA was extracted. This consists of SNP information, the entire 22,362 Canine SNP22 Beadchip used, SNP genotyping was carried out. Associated with hip phenotype for QTL detection for each SNP marker regression analysis using R statistical program (single SNP regression analysis) through the expression of hip additive effect of SNP marker for the evaluation. As the primary analysis of hip dysplasia in SNPs they have significance to the 4, 38, X chromosome respectively 11, 4, 10 results were excavated a total of 25 (genome-wise P < 0.001).

KEYWORDS

 Genome-wide association study, Single nucleotide polymorphism, Canine, hip dysplasia, Marker

ACKNOWLEDGEMENTS

This study was supported by awards from the AGENDA project (grant no. PJ11950032017) of the National Institute of Animal Science, Rural Development Administration, South Korea.

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