Journal of Animal Breeding and Genomics (J Anim Breed Genom)
Zewdu Edea1, Hailu Dadi2, Tadelle Dessie3, and Kwan-Suk Kim1*
1Department of Animal Science, Chungbuk National University, Cheongju, Korea
2Department of Biotechnology, Addis Ababa Science and Technology University, P.O. Box 16417, Addis Ababa, Ethiopia
3International Livestock Research Institute (ILRI), P.O. Box 5689, Addis Ababa, Ethiopia
Correspondence to Kwan-Suk Kim, E-mail: kwanskim@chungbuk.ac.kr
Volume 2, Number 3, Pages 151-162, June 2018.
Journal of Animal Breeding and Genomics 2018, 2(3), 151-162. https://doi.org/10.12972/jabng.20180030
Received on 30 August, 2018, Revised on 21 September, 2018, Accepted on 21 September, 2018, Published on September 30, 2018.
Copyright © 2018 Korean Society of Animal Breeding and Genetics.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
The objective of the study was to identify signatures of divergent selection associated with production and adaptive traits in Ethiopian and Hanwoo cattle by using a high-density and informative SNPs (80K) specifically developed from Bos indicus breeds. The most highly differentiated regions representing the top 1% windows were used to define genomic regions under divergent selection. Based on population genetic differentiation (FST) analysis, a total of 334 genes were identified in the comparison of Ethiopian cattle with Korean cattle (Hanwoo). The genes are associated with thermotolerance (DNAJB5/Hsp40), pigmentation (ALX3, DCTN2, and MYO1A), reproduction/fertility (INHBC, UBE2D3, ID3, PAIP2, and PSPC1), and body stature and production traits (MBP2, HERC3, and GJB3 and POLR2A) and carcass quality (TFEC, MYOT, and PARPA). Functional enrichment analysis further showed that the candidate genes were associated with pathways relevant for physiological adaptation, including vasopressin-regulated water reabsorption, Rap1 signaling, PIK3 signaling, and melanogenesis to extreme environments. By comparing cattle breeds with distinct evolutionary and breeding legacies, we spotted candidate genes under selection and pathways which may contribute to further understanding of the consequence of natural and/or artificial selection in molding the phenotypic diversity of modern cattle breeds.
Bos indicus, Hanwoo, candidate genes, high-density SNPs, Indicus chip
The authors declare that there is no conflict of interest with any financial organization concerning the material discussed in the manuscript.
This study was supported by the grant from Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (No. 318015031SB010) in Korea.