Journal of Animal Breeding and Genomics (J Anim Breed Genom)
Yuju Lee1†, Dain Lee2†, Tae-Hee Kim1, Minhwan Jeong2, Julan Kim2, Hyejin Kim2, Chaehyeon Lim2, Yoonji Chung3, Yeongkuk Kim4, Min-Sung Kim5, Seung-Hwan Lee3, Woojai Lee5, Hyun-Chul Kim2*, Hee-Bok Park1,6*
1Department of Animal Resources Science, Kongju National University, Yesan, 32439, Korea
2Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Korea
3Division of Animal and Dairy Science, Chungnam National University, Deajeon 34134, Korea
4Quantomic, Deajeon 34167, Korea
5BLUGEN, Busan 48071, Korea
6Resource Science Research Institute, Kongju National University, Yesan 32439, Korea
Correspondence to Hee-Bok Park, E-mail: heebokpark@kongju.ac.kr
†These authors contributed equally to this work.
Volume 8, Number 4, Pages 117-126, December 2024.
Journal of Animal Breeding and Genomics 2024, 8(4), 117-126. https://doi.org/10.12972/jabng.20240404
Received on 29 November, 2024, Revised on 09 December, 2024, Accepted on 10 December, 2024, Published on 31 December, 2024.
Copyright © 2024 Korean Society of Animal Breeding and Genetics.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
Olive flounders (Paralichthys olivaceus) hold significant economic values in the aquaculture sector of South Korea. Scuticociliatosis, caused by several parasite species, poses an important threat to the aquaculture industry, particularly in olive flounders. Developing resistance to this disease is vital for sustainable aquaculture. In this study, we performed a genome-wide association study (GWAS) to identify genetic loci associated with Scuticociliatosis resistance in olive flounders. Using a time-to-event survival data as phenotype, we analyzed genomic data to detect loci affecting the Scuticociliatosis resistance. We identified the loci associated with the disease and the positional candidate genes, including NEK7, ZNF362B, PTPRUb, COL13A1, RB1, DPYSL5, and PC. Further KEGG pathway analysis revealed significant enrichment in biological pathways such as ECM-receptor interaction, Focal adhesion, Platelet activation, Rap1 signaling, and Inositol phosphate metabolism, which are closely related with immune and inflammation responses. These findings provide insight into the genetic architecture of Scuticociliatosis resistance and can assist the development of breeding strategies for disease-resistant olive flounder.
Scuticociliatosis, Time-to-event survival data, Genome-wide association study, biological pathways, Olive f lounder
이 논문은 국립수산과학원(수산과학연구사업 R2024032)의 지원으로 수행되었습니다.
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