Journal of Animal Breeding and Genomics (J Anim Breed Genom)
Do Hyun Kim, Jae Don Oh*
Dept of Animal Biotechnology, Jeonbuk National University, Jeonju 54896, Korea
Correspondence to Jae Don Oh, E-mail: oh5ow@naver.com
Volume 7, Number 3, Pages 65-73, September 2023.
Journal of Animal Breeding and Genomics 2023, 7(3), 65-73. https://doi.org/10.12972/jabng.20230008
Received on 07 July, 2023, Revised on 20 September, 2023, Accepted on 22 September, 2023, Published on 30 September, 2023.
Copyright © 2023 Korean Society of Animal Breeding and Genetics.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
This study was conducted to explore the genomic information significantly associated with the pH concentration of Hanwoo meat and to perform functional interpretation of the candidate genes. pH concentrations were measured from 135 samples of Hanwoo, and SNP information was generated using the Hanwoo GeneChip v1. The phenotype of pH concentration and SNP information were used in GWAS (Genome-Wide Association Study). A total of 44 significant SNPs were detected in the analysis (p-value < 0.001). Chromosome 29 had the highest number of significant SNPs (6 SNPs), Chromosome 7 with the second-highest number (5 SNPs). Gene ontology (GO) and KEGG pathway analysis using DAVID identified 3 significant GO terms in Biological Process and 1 in Cellular Component. Additionally, a total of 2 pathways were identified through KEGG analysis. The significant candidate genes were found to be closely associated with the regulation of phosphorylase enzymes or mitochondrial energy production functions. These research f indings are expected to be useful data for future development of digital breeding technologies.
genome-wide association study (GWAS), Hanwoo, pH
본 논문은 농촌진흥청 2025 축산현안대응기술 고도화 사업(PJ01621803)의 일환으로 수행되었습니다.
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