Journal of Animal Breeding and Genomics (J Anim Breed Genom)
Seungwon Oh, Duhak Yoon*
Department of Animal Science & Biotechnology, Graduate School, Kyungpook National University, Sangju, 37224, Republic of Korea
Correspondence to Duhak Yoon, E-mail: dhyoon@knu.ac.kr
Volume 6, Number 4, Pages 253-264, December 2022.
Journal of Animal Breeding and Genomics 2022, 6(4), 253-264. https://doi.org/10.12972/jabng.20220027
Received on August 04, 2022, Revised on December 23, 2022, Accepted on December 26, 2021, Published on December 31, 2022.
Copyright © 2022 Korean Society of Animal Breeding and Genetics.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
This study analyzed linkage disequilibrium (LD) and effective population size (Ne) to understand structural characteristics such as genetic diversity and historical events of the Hanwoo cow population using Illumina SNP50K BeadChip. The genomic DNA was prepared through the hair roots of 2,076 Hanwoo cows in Gyeongbuk province and 941 Hanwoo cows in Jeonbuk province, and a total of 53,866 and 50,908 SNP were obtained, respectively. For analysis, 2,058 samples and 41,449 SNP were selected in Gyeongbuk, and 941 samples and 35,863 SNP were selected in Jeonbuk through a QC. LD (r2) by the distance between pairwise SNP was calculated, and the average r2 was 0.05 ± 0.10 in Gyeongbuk, and 0.04 ± 0.07 in Jeonbuk. r2 was shown to be 0.23 ± 0.29 at 0-50 kb and 0.12 ± 0.19 at 50-100 kb in Gyeongbuk, and 0.21 ± 0.26 at 0-50 kb and 0.11 ± 0.18 at 50-100 kb in Jeonbuk. The past effective population size was 994 heads in 69 generation ago but decreased to 267 heads in 13 generation ago in Gyeongbuk, 1,588 heads in 70 generation ago but decreased to 415 heads in 13 generation ago in Jeonbuk. As a result, it was confirmed that LD decayed by the physical distance between SNP, and the genetic diversity of Hanwoo cows gradually declined. It might be in urgent need of a conservation plan that includes a cow-customized genetic management program.
Single Nucleotide Polymorphism (SNP), Linkage Disequilibrium, Effective population size, Genetic diversity, Hanwoo cow
본 연구는 농촌진흥청 바이오그린연계 농생명혁신기술개발사업(과제번호: PJ 015658022022)의 지원에 의해 이루어진 것입니다. 연구비 지원에 감사드립니다.
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